No 720135

This is a partial list of unnumbered minor planets for principal provisional designations assigned between 1 January and 15 September 1999. As of June 2024, a total of 400 bodies remain unnumbered for this period.Objects for this year are listed on the following pages: A–R · S–T and U–Y. Also see previous and next year.

In a RGB color space, hex #720135 is composed of 44.7% red, 0.4% green and 20.8% blue. Whereas in a CMYK color space, it is composed of 0% cyan, 99.1% magenta, 53.5% yellow and 55.3% black. It has a hue angle of 332.4 degrees, a saturation of 98.3% and a lightness of 22.5%. #720135 color hex could be obtained by blending #e4026a with #000000. Closest websafe color is: #660033.

The hexadecimal color #720135 has RGB values of R:114, G:1, B:53 and CMYK values of C:0, M:0.99, Y:0.54, K:0.55. Its decimal value is 7471413.

• Chunyu Zhu, Jingyu Wang, Yalan Du, Chunli Li, Mengchan Hao, Yu Zhang, Xiaoqing Zhang, Yiwei Guan, Fangliang Zheng, Yuan Zhang, View ORCID ProfileJianjun Chen

doi: https://doi.org/10.1101/2023.09.04.556164

Summary

RNA viruses, such as respiratory syncytial virus and SARS-CoV-2, can generate viral circular RNAs (circRNAs), which may play important roles during viral infection. However, whether influenza A viruses have this ability to generate viral circRNAs remains unknown. In this study, we discovered that the negative-strand RNA of the H1N1 nucleoprotein (NP) gene can generate a circRNA, designated circNP37. Furthermore, we demonstrated that circNP37 positively regulated viral replication by competitively sponging host miR-361-5p which inhibited polymerase basic protein 2 (PB2) expression. These results were confirmed using in vivo experiments. Compared with wild-type virus, infection with circNP37 knockout virus resulted in a reduced viral load in the lungs. This study demonstrates, for the first time, the existence and biological function of H1N1-derived circNP37. These findings help us better understand the mechanisms of influenza virus replication and pathogenicity.

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